サルコペニア肥満と加齢による内分泌適応

サルコペニア肥満と加齢による内分泌適応に関するレビュー論文を紹介します。

Kunihiro Sakuma and Akihiko Yamaguchi. Sarcopenic Obesity and Endocrinal Adaptation with Age. International Journal of Endocrinology Volume 2013 (2013), Article ID 204164

個人的に大変お世話になっている佐久間先生の論文で、下記HPで全文見ることができます。

http://www.hindawi.com/journals/ije/2013/204164/

サルコペニア肥満に対しては多種類の運動（柔軟性トレーニング、有酸素運動、レジスタンストレーニング）と栄養療法（1日エネルギー必要量より200-750kcal少ないエネルギー投与量、高蛋白食1.5g/kgまで）が望ましく、有酸素運動単独はセカンドベストとあります。

サルコペニア肥満の原稿を執筆しなければいけないので、とても参考になります。加齢による内分泌適応のところも後でじっくり読みたいと思います。

Abstract
In normal aging, changes in the body composition occur that result in a shift toward decreased muscle mass and increased fat mass. The loss of muscle mass that occurs with aging is termed sarcopenia and is an important cause of frailty, disability, and loss of independence in older adults. Age-related changes in the body composition as well as the increased prevalence of obesity determine a combination of excess weight and reduced muscle mass or strength, recently defined as sarcopenic obesity. Weight gain increases total/abdominal fat, which, in turn, elicits inflammation and fatty infiltration in muscle. Sarcopenic obesity appears to be linked with the upregulation of TNF-, interleukin (IL)-6, leptin, and myostatin and the downregulation of adiponectin and IL-15. Multiple combined exercise and mild caloric restriction markedly attenuate the symptoms of sarcopenic obesity. Intriguingly, the inhibition of myostatin induced by gene manipulation or neutralizing antibody ameliorates sarcopenic obesity via increased skeletal muscle mass and improved glucose homeostasis. In this review, we describe the possible influence of endocrinal changes with age on sarcopenic obesity.