カルシウム摂取量とサルコペニア

カルシウム摂取量とサルコペニアの関連をみた論文を紹介します。

Seo MH, Kim MK, Park SE, Rhee EJ, Park CY, Lee WY, Baek KH, Song KH, Kang MI, Oh KW. The association between daily calcium intake and sarcopenia in older, non-obese Korean adults: the fourth Korea national health and nutrition examination survey (KNHANES IV) 2009. Endocr J. 2013 Jan 26. [Epub ahead of print]

対象は正常体重の高齢者1339人です。サルコペニアは四肢骨格筋量÷体重が若年の2SD以下の場合としています。結果ですが、カルシウム摂取量は体脂肪率と負の相関、四肢骨格筋量と正の相関をそれぞれ認めました。サルコペニアの高齢者は夕にカルシウム摂取量が少なかったです。

カルシウム摂取量で3群に分類すると、サルコペニアの有病割合は、少ない群で6.3%、中央群で4.3%、多い群で2.7%でした。年齢、性別、BMI、総エネルギー摂取量、ライフスタイルで調整後も、カルシウム摂取とサルコペニアに独立した関連を認めました。

カルシウム摂取量とサルコペニアに関連を認めることは納得できますが、因果関係ではないと思います。カルシウム摂取不足が顕著なサルコペニアの高齢者に、カルシウムのサプリメントを使用することはありえます。カルシウム投与がサルコペニア治療に有用とは考えにくいです。

Abstract

Recent data suggest that variations in calcium intake may influence body weight and composition; however, the relationship between daily calcium intake and muscle mass has not been well established. The objective of this study was to assess the relationship between daily calcium intake and sarcopenia. We analyzed data for older adults (over 60 years) from the fourth Korea National Health and Nutrition Examination Survey (KNHANES) conducted in 2009. A total of 1339 Non-Obese (BMI between 18.5 and 25 kg/m(2)), older adults (592 men and 707 women) were enrolled. Dietary variables were assessed using a nutrition survey that used a 24-hour recall method. Daily calcium intake based on the consumption of each food item was calculated. Sarcopenia was defined as an appendicular skeletal muscle mass divided by body weight less than 2 SD below the sex-specific mean for young adults. We found that daily calcium intake was negatively correlated with total body fat percentage and positively correlated with appendicular skeletal mass (p<.001). Participants with sarcopenia
appear to have significantly lower daily calcium intakes than participants without sarcopenia (p<.001) The unadjusted prevalence of sarcopenia according to daily calcium intake tertiles were 6.3%, 4.3%, and 2.7% in tertiles 1, 2, and 3, respectively. After adjustment for age, sex, BMI, total energy intake, and lifestyle factors, compared with those in the lowest tertile of daily calcium intake, participants in the highest tertile had an odds ratio for sarcopenia of 0.295 (95% confidence interval, 0.087-0.768; p for trend = 0.014). We found that daily calcium intake, corrected for total energy intake and serum 25(OH)D status, was significantly lower in subjects with sarcopenia than in those without. Our results suggest a strong inverse association between daily calcium intake and sarcopenia in non-obese, older Korean adults.