レスベラトロールによる骨格筋萎縮の動物実験

レスベラトロールでがんによる骨格筋萎縮と心臓萎縮が抑制されたというマウスの動物実験の研究です。

Shadfar S, Couch ME, McKinney KA, Weinstein LJ, Yin X, Rodriguez JE, Guttridge DC, Willis M. Oral Resveratrol Therapy Inhibits Cancer-Induced Skeletal Muscle and Cardiac Atrophy In Vivo. Nutr Cancer. 2011 Jun 8:1. [Epub ahead of print]

レスベラトロールとは、ぶどうの皮や赤ワインに含まれる成分で、ポリフェノール、抗酸化物質の1つです。マウスによる動物実験レベルでは、レスベラトロールを毎日経口摂取することで、骨格筋萎縮と心臓萎縮が有意に抑制されました。

ヒトでの臨床研究はこれからのようですので、今すぐ赤ワインを毎日飲む必要はありません。ただ、抗炎症作用があるかもしれませんので、名前は覚えておいてもよいと思います。

Abstract
The mechanism by which cancer mediates muscle atrophy has been delineated in the past 3 decades and includes a prominent role of tumor-derived cytokines, such as IL-6, TNFα, and IL-1. These cytokines interact with their cognate receptors on muscle to activate the downstream transcription factor NF-κB and induce sarcomere proteolysis. Experimentally, inhibiting NF-κB signaling largely prevents cancer-induced muscle wasting, indicating its prominent role in muscle atrophy. Resveratrol, a natural phytoalexin found in the skin of grapes, has recently been shown to inhibit NF-κB in cancer cells, which led us to hypothesize that it might have a protective role in cancer cachexia. Therefore, we investigated whether daily oral resveratrol could protect against skeletal muscle loss and cardiac atrophy in an established mouse model. We demonstrate resveratrol inhibits skeletal muscle and cardiac atrophy induced by C26 adenocarcinoma tumors through its inhibition of NF-κB (p65) activity in skeletal muscle and heart. These studies demonstrate for the first time the utility of oral resveratrol therapy to provide clinical benefit in cancer-induced atrophy through the inhibition of NF-κB in muscle. These findings may have application in the treatment of diseases with parallel pathophysiologies such as muscular dystrophy and heart failure.