雑誌Skeletal Muscle

Skeletal Muscleという雑誌が創刊されました。オンラインで無料で全文見ることができるのが嬉しいです。Journal of Cachexia, Sarcopenia and Muscleもそうですが、無料で最新の論文を読むことができるのはありがたいことです。その分、しっかり学習しなければいけない気もしますが…。

http://www.skeletalmusclejournal.com/

臨床医学の雑誌というよりも、骨格筋の分子生物学に関する雑誌です。リハ栄養・サルコペニアの臨床に直結する論文は少ないかもしれませんが、興味深いと私が思う論文があれば紹介していきたいと思います。

今回の中では、Treating cancer cachexia to treat cancerが最も興味深いです。下記HPで全文見れます。

http://www.skeletalmusclejournal.com/content/pdf/2044-5040-1-2.pdf

抄録だけ掲載しておきます。

Abstract
Skeletal muscle wasting is a major component of cachectic states found in a variety of disease settings, including cancer. As increasing caloric intake often provides little benefit in combating muscle loss in cachectic patients, a major research focus has been to develop strategies stimulating muscle anabolic pathways – in an attempt to fight the catabolic pathways induced during cachexia. Two recent papers have reported the beneficial effects of blocking the myostatin/activin signalling pathway in mouse models of cancer cachexia. We discuss the implications of their findings both with respect to the role that this signalling pathway may play in the aetiology of cachexia and with respect to the prospects for targeting this pathway as a therapeutic strategy in patients with cachexia.

第1号内容
Review
Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models
Stefano Schiaffino, Cristina Mammucari
Skeletal Muscle 2011, 1:4 (24 January 2011)

Research
Muscle atrophy induced by SOD1G93A expression does not involve the activation of caspase in the absence of denervation
Gabriella Dobrowolny, Michela Aucello, Antonio Musaro
Skeletal Muscle 2011, 1:3 (24 January 2011)

Commentary
Treating cancer cachexia to treat cancer
Se-Jin Lee, David J Glass
Skeletal Muscle 2011, 1:2 (24 January 2011)

Editorial
Welcome to Skeletal Muscle
David J Glass, Kevin P Campbell, Michael A Rudnicki
Skeletal Muscle 2011, 1:1 (24 January 2011)